Focused Issues more

Vol 3, No 3 (September 2014): Systemic Treatment of Cutaneous and Mucosal Melanoma More >>
Vol 3, No 2 (June 2014): The Changing World of Drug Development More >>

Statistics in Oncology Clinical Trials

Phase II design: history and evolution
Larry Rubinstein
Adaptive clinical trial designs in oncology
Yong Zang, J. Jack Lee

Your Views

Widespread use of pemetrexed in oncology: has it turned it into a new drug?
Esther Una Cidon, Melania Varga, Tom Geldart, Pilar Alonso

Editorials

Can EGFR mutation status evolve with chemotherapy?
Eric S. Kim, David J. Stewart, Alok A. Khorana

Review Article

The spectrum of clinical trials aiming at personalizing medicine
Christophe Le Tourneau, Maud Kamal, Marie Alt, Loic Verlingue, Vincent Servois, Marie-Paule Sablin, Nicolas Servant, Xavier Paoletti
Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine
Sumithra J. Mandrekar, Daniel J. Sargent
From genomic data analysis to drug development: a new generation of trials using molecular marker assessment in breast cancer
Sophie Doisneau-Sixou, Nadia Harbeck
Melanoma adjuvant therapy
Prashanth M. Thalanayar, Sanjiv S. Agarwala, Ahmad A. Tarhini
Genotyping of cutaneous melanoma
Isabella C. Glitza, Michael A. Davies
Treatment of KIT-mutated metastatic mucosal melanoma
Kevin B. Kim, Anas Alrwas

Original Article

Prostate carcinoma in transgenic Lewis rats - a tumor model for evaluation of immunological treatments
Laura E. Johnson, Jordan T. Becker, Jason A. Dubovsky, Brian M. Olson, Douglas G. McNeel

Review Articles

Prevention of colorectal cancer and dietary management
Ningqi Hou, Dezheng Huo, James J. Dignam
Stage II colon cancer
David N. Church, Rachel Midgley, David J. Kerr
Mining the ACCENT database: a review and update
Lindsay A. Renfro, Qian Shi, Daniel J. Sargent
Status of hepatocellular carcinoma in South Korea
Seung Kew Yoon, Hoo Geun Chun

Statistics in Oncology Clinical Trials

Adaptive randomized phase II design for biomarker threshold selection and independent evaluation
Lindsay A. Renfro, Christina M. Coughlin, Axel M. Grothey, Daniel J. Sargent
Adaptive clinical trial designs in oncology
Yong Zang, J. Jack Lee

Updates on Surgical Oncology

Clinical trials in lung cancer surgery and research cooperation
Wen-Zhao Zhong, Hao-Ran Zhai, Yi-Long Wu